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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Synthetic Applications of γ-Hydroxybutenolides

Author(s): William H. Miles

Volume 11, Issue 2, 2014

Page: [244 - 267] Pages: 24

DOI: 10.2174/15701794113109990062

Price: $65

Abstract

γ-Hydroxybutenolides are readily available reagents that are useful starting materials for the synthesis of simple and complex compounds. This review will discuss the role tautomerism plays in the reactivity profile of γ-hydroxybutenolides, the major modes of reactivity of γ-hydroxybutenolides, and the application of this methodology for the synthesis of biologically important molecules.

Keywords: Diels-Alder reaction, Grignard reaction, γ-hydroxybutenolides, oxidation, reduction, synthesis, tautomerism.

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