Myocardial Ischemia and Reperfusion Injury: Studies Using Transgenic and Knockout Mice

W.   M.C.   Jong; H.   T.   Cate; P.   H.   Reitsma; R.   J.   de Winter

doi:10.2174/138920205774482990

Abstract

Transgenic and knockout mice are created and used for a large variety of research objectives. This overview describes the (genetically modified) mouse models that have been used to study the development of myocardial ischemia and reperfusion injury. The role of cytokines, chemokines, leukocytes, reactive oxygen species, anti-oxidants, NO, complement system, coagulation system, heat shock proteins, apoptosis and necrosis, and acute phase reactants are presented.

Keywords: Myocardial, ischemia, reperfusion, mice, inflammation, overexpression, knockout, transgene