Title:Matrix Metalloproteinases: Drug Targets for Myocardial Infarction
Volume: 14
Issue: 3
Author(s): Andriy Yabluchanskiy, Yaojun Li, Robert J. Chilton and Merry L. Lindsey
Affiliation:
Keywords:
Extracellular matrix, left ventricle, left ventricle remodeling, matrix metalloproteinases, myocardial infarction, Macrophage Infiltration, Polymorphonuclear Leukocyte Infiltration, Myofibroblast Activation, tissue inhibitors of metalloproteinases (TIMPs), Collagen
Abstract: Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Rapid advances in the
treatment of acute MI have significantly improved short-term outcomes in patients, due in large part to successes in preventing
myocardial cell death and limiting infarct area during the time of ischemia and subsequent reperfusion. Matrix
metalloproteases (MMPs) play key roles in post-MI cardiac remodeling and in the development of adverse outcomes. This
review highlights the importance of MMPs in the injury and remodeling response of the left ventricle and also discusses
their potential as therapeutic targets Additional pre-clinical and clinical research is needed to further investigate and understand
the cardioprotective effects of MMPs inhibitors.
