Title:Recent Trends in the Pharmacological Activity of Isoprenyl Phenolics
Volume: 20
Issue: 2
Author(s): M. Marin and S. Manez
Affiliation:
Keywords:
Apoptosis, cytotoxicity, diabetes, flavonoids, hydroquinones, inflammation, osteoporosis, plant estrogens, prenyl phenolics, resorcinols
Abstract: A number of prenylated phenols, mainly flavonoids, have been identified as active constituents of medicinal plants. Due to
their beneficial effects on human health, this class of compounds has received a great deal of attention, not only from the pharmaceutical
industry, but also from other areas of applied sciences, including the food, brewing, and cosmetics industries. The addition of prenyl residues
through the activity of isoprenyltransferases, the key biosynthetic enzymes for these plant metabolites, endows flavonoids with a variety
of biological activities, mostly due to improved interaction with membranes and proteins. The role of prenylated flavonoids in plants
correlates with their activities as antioxidant or anti-infectious agents. In connection with these effects, these compounds have been
evaluated for multiple potential uses, e.g. as antibacterial, antiprotozoal, antifungal, anti-inflammatory, antitumor, estrogenic, antidiabetic,
or antithrombotic agents, among others. The present review, in principle focused on phenolic derivatives containing a non-cyclized
isoprenyl chain, discusses the most relevant pharmacological reports for the period 2005-2012.
