Title:From A1 to A3 en passant Through A2A Receptors in the Hippocampus: Pharmacological Implications
Volume: 11
Issue: 6
Author(s): Ana M. Sebastiao, Filipa F. Ribeiro and Joaquim A. Ribeiro
Affiliation:
Keywords:
Adenosine receptors, brain-derived neurotrophic factor, cannabinoids, γ-aminobutyric acid, glutamate,
hippocampus, neuroprotection, vasoactive intestinal peptide, Adenosine receptors, brain-derived neurotrophic factor, cannabinoids, aminobutyric acid, glutamate, hippocampus, neuroprotection, vasoactive intestinal peptide, ACh, AMPA
Abstract: The role of A1 and A3 receptors is discussed based on data almost exclusively obtained in the hippocampus.
This brain area, where A1 receptor expression predominates, has been a matter of intensive research in the adenosine field.
Interestingly, in the last decade, the relevance of the much less expressed adenosine receptor in the hippocampus, the A2A
receptor, has been put forward. These two high affinity receptors operate as effective regulators of a number of
neurotransmitters and/or neuromodulators, through modulation of their release, action, or even inactivation. Therefore, A1
and A2A receptors constitute a must in the discussion about adenosine receptors in the hippocampus, and consequently,
about the potential implications of their pharmacological manipulation and drug targeting.
