Title:Antiangiogenic Therapeutic Approaches in Multiple Myeloma
Volume: 12
Issue: 7
Author(s): Domenico Ribatti, Giuseppe Mangialardi and Angelo Vacca
Affiliation:
Keywords:
Angiogenesis, antiangiogenesis, bortezomib, lenalinomide, multiple myeloma, thalidomide, thyrosine kinase
inhibitors, zoledronic acid, chorioallantoic membrane, Monoclonal gammopathy of undetermined significance, Platelet-derived growth factor receptor, Hypoxia inducible factor 1 alpha, chorioallantoic membrane.
Abstract: Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and has prognostic potential. The
pathophysiology of MM-induced angiogenesis involves both direct production of angiogenic cytokines by plasma cells
and their induction within the bone marrow microenvironment. An improved understanding of the importance of
angiogenesis-related signaling in MM has allowed for the rational use of antiangiogenic therapies in this tumor. This
review article summarizes the literature data concerning the employment of the most important antiangiogenic therapeutic
agents actually used in preclinical models and clinical settings for the treatment of MM.
