Title:Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy
Volume: 12
Issue: 2
Author(s): Frank Spillmann, Sophie Van Linthout and Carsten Tschope
Affiliation:
Keywords:
Diabetes mellitus, dysfunction, endothelial dysfunction, glucose metabolism, high-density lipoprotein, remodeling
Abstract: Diabetic cardiopathy includes a specific cardiomyopathy, which occurs in the absence of coronary heart disease
and hypertension under diabetes mellitus. Hyperglycemia, hyperinsulinemia, and hyperlipidemia, characteristic metabolic
disturbances evident in diabetes mellitus, all three lead to a specific altered cardiac structure and function. Recently, it has
been demonstrated that altered HDL, be it low HDL or dysfunctional HDL is not only a consequence of diabetes mellitus,
but can also contribute to the development of diabetes mellitus, and therefore also of diabetic cardiomyopathy. This
review summarizes how HDL can indirectly affect diabetic cardiomyopathy via their influence on the metabolic triggers
hyperglycemia, hyperinsulinemia, and hyperlipidemia, and how they can directly influence the cardiac cellular
consequences, typical for diabetic cardiomyopathy, including inflammation, oxidative stress, apoptosis, fibrosis, Ca2+
handling, glucose homeostasis, and endothelial dysfunction.
