Title: Depression in Sleep Related Breathing Disorder
Volume: 3
Issue: 4
Author(s): Shyam Subramanian, Mary Rose and Salim Surani
Affiliation:
Keywords:
Depression in OSA, sleep and depression, OSA and mood disorder, OSA and sleep disruption
Abstract: Sleep deprivation and sleep disruption have long been associated with mood disorders, both as a cause as well as an effect. Sleep-disordered breathing results in significant and persistent sleep disruption, which in turn leads to significant neurocognitive deficits [1,2] and major depression [3-6]. Various pathophysiologic mechanisms may play a role in modulating mood changes in these patients. Treatment for sleep-disordered breathing often improves mood [4, 7], though the data may suggest a placebo response [8]. Patients with sleep-disordered breathing should be carefully screened for mood disorders, and patients with major depression should be screened for possible underlying sleep-disordered breathing.
