Title: Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis
Volume: 11
Issue: 3
Author(s): Govardhan K. Shroff, Ramyasri Kuna, Kethora Dirsipam, Ravishekar Yalagala and Prasenjit Mitra
Affiliation:
Keywords:
Warburg effect, glutaminolysis, aerobic glycolysis, Myc, Akt, mTOR, Hexokinase II, SGLT2 expression, mitochondrial outer membrane, isozymes, Fibroblast growth factor receptor (FGFR), Pyruvate kinase, tumor cell populations, hypoxic tumor cells
Abstract: Altered cellular metabolism is a hallmark of tumorigenesis. Described first in 1924 by Otto Warburg, a cancer cell undergoes complete metabolic reprogramming to attain nutrient self-sufficiency for proliferation and survival. Interplay between diverse signalling cascades confers this metabolic advantage. In this review we focus on signalling molecules that regulate this altered metabolic paradigm in a cancer cell with emphasis on small molecule mediated intervention for attenuation of growth and progression of tumor.
