Title:Progress of Angiogenesis Signal Pathway and Antiangiogenic Drugs in
Nasopharyngeal Carcinoma
Volume: 17
Author(s): Yunzhi Zhu, Yi Hu, Chengsheng Yang, Shipu Huang, Jianping Wen*, Weiguo Huang*Shengjun Xiao*
Affiliation:
- Hunan Medical College General Hospital, Huaihua 418000, China
- Guangxi Key Laboratory of Tumor Immunity and Microenvironment Regulation, Guilin Medical University, Guilin 541199, China
- Department of Pathology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, China
- Guangxi Key Laboratory of Tumor Immunity and Microenvironment Regulation, Guilin Medical University, Guilin 541199, China
- Department of Pathology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, China
Keywords:
Nasopharyngeal carcinoma, Antiangiogenic drugs, Signaling pathways, Molecular targeted therapy.
Abstract: Nasopharyngeal cancer is a rare cancer with unique ethnic and geographic distribution. Since nasopharyngeal cancer often originates from the
pharyngeal crypt, early symptoms are not obvious. They are difficult to detect in time, and the disease is usually diagnosed and treated only when it
has progressed to an advanced-stage. Since angiogenesis is essential for the growth and invasion of solid tumors, antiangiogenic therapy has
become a common treatment strategy for many solid tumors, and it has also achieved remarkable results in the treatment of nasopharyngeal
carcinoma, which is prone to recurrence and distant metastasis. In this paper, we review the latest research progress of antiangiogenic drugs for
nasopharyngeal carcinoma and their antiangiogenic mechanism of action and further propose some promising antiangiogenic therapeutic targets.
