Title:Role of Multi-parameter-based Cardiac Magnetic Resonance in the Evaluation
of Patients with Coronary Heart Disease Combined with Heart Failure
Volume: 20
Author(s): Ying Yu, Bihong Liao, Jingjing Zhang, Jin Zou, Jia Deng, Jiaqi Liu, Gang Wang, Yueyan Li, Fengcui Qian, Hong Huang, Qiuyu Wang*, Jinwei Tian*Huifang Tang*
Affiliation:
- Hunan Provincial Key Laboratory of Multi-omics And Artificial Intelligence of Cardiovascular Diseases, University of South China, Hengyang,
Hunan, 421001, China
- Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
- Department of Cardiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
Keywords:
Cardiac magnetic resonance, Coronary heart disease, Heart failure, Strain, T1 mapping, Left ventricular remodeling. Article
Abstract:
Background:
Coronary Heart Disease (CHD) is one of the most common types of cardiovascular disease, and Heart Failure (HF) is an important factor in its
progression. We aimed to evaluate the diagnostic value and predictors of multiparametric Cardiac Magnetic Resonance (CMR) in CHD patients
with HF.
Methods:
The study retrospectively included 145 CHD patients who were classified into CHD (HF+) (n = 91) and CHD (HF–) (n = 54) groups according to
whether HF occurred. CMR assessed LV function, myocardial strain and T1 mapping. Multivariate linear regression analyses were performed to
identify predictors of LV dysfunction, myocardial fibrosis, and LV remodeling.
Results:
CHD (HF+) group had impaired strain, with increased native T1, ECV, and LVM index. The impaired strain was associated with LVM index (p <
0.05), where native T1 and ECV were affected by log-transformed amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. ROC
analysis showed the combination of global circumferential strain (GCS), native T1, and LVM had a higher diagnostic value for the occurrence of
HF in CHD patients.
Meanwhile, log-transformed NT-proBNP was an independent determinant of impaired strain, increased LVM index, native T1 and ECV.
Conclusion:
HF has harmful effects on LV systolic function in patients with CHD. In CHD (HF+) group, LV dysfunction is strongly correlated with the degree
of LV remodeling and myocardial fibrosis. The combination of the three is more valuable in diagnosing HF than conventional indicators.
