Title:Identifying Predictors for Hypoplastic Aortic Arch (HAA) in Pediatric Patients
with Complex Coarctation of the Aorta (CoA)
Volume: 20
Author(s): Ying Lyu, Lu Tian, Bin Qin, Xiao Fan and Ling He*
Affiliation:
- Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders,
Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory
Diseases, Chongqing 400014, China
Keywords:
children, hypoplastic aortic arch, coarctation of aorta, aortic diseases, congenital heart disease, computed tomography.
Abstract:
Objective:
HAA is a significant risk factor in complex CoA patients. We conducted a retrospective study to explore the relationship between HAA and other
cardiovascular factors.
Methods:
We analyzed 103 patients diagnosed with complex CoA using CT angiography and echocardiography. Aortic diameter was measured at six levels,
and severe coarctation was defined as coarctation site to diaphragmatic level ratio (CDR) < 50%. Correlations between non-HAA and HAA groups
were assessed. Univariate and multivariate logistic regression identified HAA risk factors.
Results:
Among 103 children with complex CoA, 55 were in the non-HAA group and 48 in the HAA group. The incidence of PDA (56.3% vs. 32.7%, p <
0.05), severe coarctation (CDR < 50%, 81.3% vs. 34.5%, p < 0.01), and collateral arteries (39.6% vs. 0, p < 0.01) were higher in the HAA group
than one in the non-HAA group. The aortic arch size was positively correlated with age and negatively correlated with severe coarctation, VSD,
collateral arteries, and left heart dysfunction. Logistic regression results showed that collateral arteries were risk factors for the whole aortic arch
(proximal arch OR = 11.458; p < 0.01, distal arch OR = 4.211; p < 0.05, and isthmus OR = 11.744; p < 0.01), severe coarctation (OR = 6.653; p <
0.01), and left heart dysfunction (OR = 5.149; p < 0.01) associated with isthmus hypoplasia.
Conclusion:
This study highlights the prevalence of HAA in complex CoA patients and its associations with various cardiovascular factors. These insights
improve diagnosis and treatment approaches.
