Title:Relationship between Compound α-Ketoacid and Microinflammation in
Patients with Chronic Kidney Disease
Volume: 30
Issue: 8
Author(s): Zaobin Chen, Yongda Lin, Jiali Wang, Kaijin Yao, Yina Xie, Xiutian Chen and Tianbiao Zhou*
Affiliation:
- Department of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
Keywords:
Compound α-Ketoacid, chronic kidney disease, micro inflammatory, nitrogen-containing metabolites, oxidative stress, gut microbiota, abnormal lipid metabolism.
Abstract: Chronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the
kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence
rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory
state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal
function, and plays a crucial role in the pathophysiology and progression of the disease. Simultaneously,
compound α-Ketoacid can bind nitrogen-containing metabolites in the blood and accelerate their excretion
from the body, thereby reducing the level of metabolic waste, alleviating gastrointestinal reactions in patients,
and reducing the inflammatory response and oxidative stress state of the body. Compound α-Ketoacid contains
amino acids required by CKD patients. In this review, we explore the relationship between compound α-Ketoacid
and microinflammation in patients with CKD. The review indicated that compound α-Ketoacid can improve
the microinflammatory state in CKD patients by improving the nutritional status of CKD patients, improving
patient's acid-base balance disorder, regulating oxidative stress, improving gut microbiota, and regulating
abnormal lipid metabolism.
