Title:Ocular Drug Delivery of Nanoparticles for Glaucoma
Volume: 19
Author(s): Aastha Dangwal*, Vikas Bhatt and Shiv Kumar Gupta
Affiliation:
- Pharmaceutics, Vikas Bhatt, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, India
Keywords:
IOP - Intra Ocular Pressure, HPH- High Pressure Homogenization, ACG - Angle-closure glucoma, OAG - open-angle glucoma, SLN - Solid Lipid Nanoparticles, HSH - High Speed Homogenization
Abstract: The nasolacrimal channels drain the medication from the pre-corneal area, causing the
majority of the ophthalmic medication to be quickly removed following topical instillation. Over the
past thirty years, newer medical techniques, such as in situ gel, nanoparticle, liposome, nanosuspension,
microemulsion, iontophoresis, and occuserts have been created in an effort to overcome these
challenges. These methods gradually and deliberately boost the drug's bioavailability. This article
discusses ocular drug delivery for ophthalmics and its ideal characteristics, and also provides an insight
on the use of nanotechnology in the form of nanoparticles used for the treatment of glaucoma
in the eyes, employing HPH, ultrasonication/HSH, SE, SED technique, SFM, ME technique, SD
method, DE method, PM, FUD, and other techniques to offer continuous and controlled IOP inside
the eye chamber, make drug more ocularly bioavailable, and address a few pharmacological difficulties
in ophthalmology. The creation of new drug delivery methods is currently gaining popularity,
and this can facilitate the development of medicines for diseases that endanger eyesight.
