Title:PLGA, a Hauler for Anticancer Drugs: Review
Volume: 20
Author(s): Anubhav Garg, Komal, Parul Gupta, Sachin, Shubham Sharma, Shubham Kumar, Sushil Kumar, Urvashi, Rupinder Kaur, Priyanka Kriplani*Kumar Guarve
Affiliation:
- Guru Gobind Singh College of Pharmacy, Yamuna Nagar 135001, Haryana, India
Keywords:
PLGA, CANCER, FORMULATIONS, anti-inflammatory, grades, cancer, brain cancer, prostate cancer, liver cancer, breast cancer, ovarian cancer, pancratic cancer
Abstract: Polymers are the mainstay of drug delivery systems. They may be natural, semisynthetic,
or synthetic and used to program the release of drugs as per requirement. They are used to enhance
the bioavailability and hence solubility, stability, and site specificity, or to release to drug either in a
controlled, pulsatile, sustained, immediate release pattern. In the present review, we have discussed
the recent prose and patents of poly(lactic-co-glycolic acid) and PLGA applicability in preparing
formulations against cancer. Synthetic polymer, PLGA comprises monomers of glycolide and lactide
available in various grades with varying physicochemical properties thus serving the formulators to
fabricate preparations having designed release patterns. In this review, current literature and patents
of poly(lactic-co-glycolic acid); PLGA using anticancer preparations have been covered. PLGA has
demonstrated its potential as a polymer to program the release of drugs as a coating polymer and the
development of a matrix in various drug delivery systems. It can augment the bioavailability of the
drug reducing the toxicity/side effects and delivering the drug at the target site. The potential of
PLGA to transfer the drug may unclutter novel ways for therapeutic interventions in various tumors.
