The Role of Bile Acids in Pancreatic Cancer

Yanling      Wang; Haiyan      Xu; Xiaofei      Zhang; Jingyu      Ma; Shengbai      Xue; Daiyuan      Shentu; Tiebo      Mao; Shumin      Li; Ming      Yue; Jiujie      Cui; Liwei      Wang

doi:10.2174/0115680096281168231215060301

Abstract

Bile acids are well known to promote the digestion and absorption of fat, and at the same time, they play an important role in lipid and glucose metabolism. More studies have found that bile acids such as ursodeoxycholic acid also have anti-inflammatory and immune-regulating effects. Bile acids have been extensively studied in biliary and intestinal tumors but less in pancreatic cancer. Patients with pancreatic cancer, especially pancreatic head cancer, are often accompanied by biliary obstruction and elevated bile acids caused by tumors. Elevated total bile acid levels in pancreatic cancer patients usually have a poor prognosis. There has been controversy over whether elevated bile acids are harmful or beneficial to pancreatic cancer. Still, there is no doubt that bile acids are important for the occurrence and development of pancreatic cancer. This article summarizes the research on bile acid as a biomarker and regulation of the occurrence, development and chemoresistance of pancreatic cancer, hoping to provide some inspiration for future research.

Keywords: Bile acids, pancreatic cancer, biomarker, carcinogenesis, progression of cancer, chemoresistance.

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DOI https://dx.doi.org/10.2174/0115680096281168231215060301	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576

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