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Cardiovascular & Hematological Agents in Medicinal Chemistry

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ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

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Research Article

Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats

Author(s): Ismail Bouadid, Adil Qabouche and Mohamed Eddouks*

Volume 22, Issue 4, 2024

Published on: 24 January, 2024

Page: [432 - 440] Pages: 9

DOI: 10.2174/0118715257251651231212045407

Price: $65

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Abstract

Aims: The antihypertensive activity of Daphne gnidium was tested.

Background: Daphne gnidium (Thymelaeaceae) is used against hypertension.

Objective: The antihypertensive effect of Daphne gnidium was evaluated in this study.

Methods: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.

Results: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.

Conclusion: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.

Keywords: Daphne gnidium (L.), hypertension, vasorelaxant, receptor-activated calcium channels (ROCCs), ACE-2, antihypertensive.

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