Title:Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions
Volume: 22
Issue: 3
Author(s): Deepansh Mody, Priyanka Joshi, Monika Antil, Rakesh K. Gupta and Vibha Gupta*
Affiliation:
- Department of
Biotechnology, Jaypee Institute of Information Technology, Sector-62, Noida, U.P., 201307, India
Keywords:
Kinases, therapeutics, ESKAPE, antimicrobial resistance, kinase inhibitors, two-component systems.
Abstract: Multidrug-resistant ESKAPE pathogens are the leading cause of hospital-acquired
infections across the globe, posing challenges for clinicians. Random genetic mutations and constant
exposure to antibiotics in healthcare settings result in strains resistant to commonly used
antibiotics, creating life-threatening conditions. If the magic of “antibiotics” is to be sustained, a
new class of antimicrobials against novel targets is urgently needed. This necessitates understanding
and identifying novel biochemical pathways and bacterial virulence factors that can be
targeted for therapeutic interventions. Keeping in view the unambiguous role of the kinome in
bacterial survival and virulence, this review provides a survey of effector bacterial kinases involved
in evading host immune responses and drug resistance. The formation of biofilms is a
critical feature associated with the pathogenesis and survival of ESKAPE organisms in the hostile
host milieu. Hence, kinases involved in the biofilm pathway are also elucidated for clinical
relevance. In addition, endeavors in the development of therapeutics against ESKAPE kinases
are also summarized to provide direction to researchers pursuing the field.
