Title:Cu-Co Bimetallic Catalyst-based Electrochemical Sensing Platform for
Determination of Bisoprolol in Clinical Samples
Volume: 27
Issue: 12
Author(s): Mohammad Reza Salemi, Shahla Fathi, Fereshteh Chekin*Banafsheh Norouzi
Affiliation:
- Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Keywords:
Bisoprolol, bimetallic nanocatalyst, galvanic displacement, electrochemical sensor, clinical samples, Cu-Co bimetallic catalyst-based.
Abstract:
Background: Bisoprolol (BIS) is a selective beta-blocker. It has been successfully
used to treat hypertension and angina pectoris. An overdose of BIS can lead to serious complications.
An overdose is a medical emergency that requires immediate medical attention to overcome
the adverse effects of the overdose. Hence, sensitive, reliable, and cost-effective methods
are required for the determination of BIS.
Methods: In this work, a new electrochemical sensing platform based on a bimetallic catalyst was
developed for the determination of BIS. The Cu-Co nanocatalyst was easily synthesized by galvanic
displacement onto a carbon paste electrode (CPE). Then, field emission scanning electron
microscopy (FESEM), energy dispersive spectroscopy (EDS), and cyclic voltammetry (CV) were
utilized for the characterization of the Cu-Co catalyst.
Results: The galvanic displacement of Cu metal significantly affected the electro-catalytic behavior
of the Cu-Co catalyst and the Cu-Co/CPE electrode displayed a very sensitive and accurate
response towards BIS. Under optimized conditions, the response was linear in the 3 to 120 μM
concentration range, sensitivity of 631.1 μA mM-1 and a detection limit of as low as 0.4 μM using
cyclic voltammetry. The simple proposed method was also successfully employed in the analysis
of BIS in biological and pharmaceutical samples. The advantages of Cu-Co/CPE are its fast and
simple manufacturing and the possibility of a repeated surface regeneration of the sensing platform,
as well as its application for the detection of BIS in tablets and biological samples, making
Cu-Co significant promise for use in clinical diagnostics. Besides, the synthesized catalysts
showed excellent reusability and stability.
Conclusion: The presence of Cu metal due to galvanic displacement increased the sensitivity. These
findings suggest that the new nanocatalyst has potential applications in sensors and electronics.
