Title:Molecular Insight into the Apoptotic Mechanism of Cancer Cells: An
Explicative Review
Volume: 17
Author(s): Dipanjan Karati and Dileep Kumar*
Affiliation:
- Poona College of Pharmacy, Pune 411038, India
Keywords:
Apoptosis, ROS, CDK, JAK inhibitors, Pyroptosis, Mitophagy, Cardiac glycosides.
Abstract:
Mitosis of somatic cells produces a daughter cell. Apoptosis, a naturally programmed cellular death mechanism, kills abnormal cells produced by
mitosis. Cancer can develop when this equilibrium is disrupted, either by an upsurge in cell propagation or a reduction in tissue demise. Cancer
therapy aims to cause cancer cells to die while inflicting little harm to healthy cells. This review of apoptotic mechanism processes improves our
understanding of how certain malignancies begin and develop. The current cancer treatments can operate either by inducing apoptosis or causing
direct cell damage. An insight into the resistance to apoptosis may explicate why malignancy treatments fail in some situations. New therapies
grounded on our understanding of apoptotic processes are being developed to induce apoptosis of cancer cells while limiting the simultaneous
death of normal cells. Various biological activities require redox equilibrium to function properly.
Antineoplastic medications that cause oxidative stress by raising ROS and blocking antioxidant mechanisms have recently attracted much interest.
The rapid accumulation of ROS impairs redox balance and damages cancer cells severely. Here, we discuss ROS-instigating malignancy therapy
and the antineoplastic mechanism used by prooxidative drugs.
