Title:In-silico, in-vitro and in-vivo Biological Activities of Flavonoids for the
Management of Type 2 Diabetes
Volume: 21
Issue: 5
Author(s): Jyoshna Rani Dash, Biswakanth Kar*Gurudutta Pattnaik
Affiliation:
- School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha, 751003,
India
Keywords:
Diabetes mellitus, flavonoids, macrovasular complications, neuropathic pain, insulin, macrovasular complications.
Abstract: In spite of the fact that many medicinal plants have been truly utilized for the management
of diabetes all through the world, very few of them have been reported scientifically. Recently, a
diverse variety of animal models have been established to better understand the pathophysiology of
diabetes mellitus, and new medications to treat the condition have been introduced in the market.
Flavonoids are naturally occurring substances that can be found in plants and various foods and may
have health benefits in the treatment of neuropathic pain. Flavonoids have also been shown to have
an anti-inflammatory impact that is significant to neuropathic pain, as indicated by a decrease in
several pro-inflammatory mediators such TNF-, NF-B IL-6, and IL-1. Flavonoids appear to be a viable
novel therapy option for macrovasular complications in preclinical models; however, human
clinical data is still inadequate. Recently, several in silico, in-vitro and in-vivo aproaches were made
to evaluate mechanisms associated with the pathogenesis of diabetes in a better way. Screening of
natural antidiabetic agents from plant sources can be analysed by utilizing advanced in-vitro techniques
and animal models. Natural compounds, mostly derived from plants, have been studied in
diabetes models generated by chemical agents in the majority of research. The aim of this work was
to review the available in silico, in-vitro and animal models of diabetes for screening of natural antidiabetic
agents. This review contributes to the scientist's design of new methodologies for the development
of novel therapeutic agents having potential antihyperglycemic activity.
