Title:Chemistry and Therapeutic Aspect of Triazole: Insight into the Structure-activity Relationship
Volume: 29
Issue: 34
Author(s): Shikha Sharma*, Nitin Mittal and Bimal Krishna Banik
Affiliation:
- Department of Pharmaceutical Science, Lords University, Alwar 301028, India
Keywords:
Analgesic, anti-inflammatory, anthelmintic, triazole, antimicrobial, SAR.
Abstract: The triazole ring is a highly significant heterocycle that occurs naturally in many commodities and
is a common feature in pharmaceuticals. Recently, heterocyclic compounds and their derivatives have been
getting a lot of attention in medicinal chemistry because they have a lot of pharmacological and biological potential.
For example, a lot of drugs have nitrogen-containing heterocyclic moieties. The triazole ring is often
used as a bio-isostere of the oxadiazole nucleus. The oxygen atom in the oxadiazole nucleus is replaced by
nitrogen in the triazole analogue. This article explores the pharmacological properties of the triazole moiety,
including but not limited to antibacterial, analgesic, anticonvulsant, anthelmintic, anti-inflammatory, antitubercular,
antimalarial, antioxidant, antiviral, and other properties. Additionally, we discuss the diverse multi-
target pharmacological activities exhibited by triazole-based compounds. Based on a literature review, it is
evident that triazole-based chemicals hold significant potential for various applications.