Title:Association of PD-L1 Expression with Clinicopathologic Characters
in Gastric Cancer: A Comprehensive Meta-analysis
Volume: 31
Issue: 21
关键词:
PD-L1，程序性死亡配体-1,B7-H1，胃癌，临床病理特征，癌症。
摘要:
Purpose: The expression level of programmed death ligand-1(PD-L1) in patients
with gastric cancer is the key to determining the use of immune drugs. The relationship
between PD-L1 expression level and clinical characteristics is worth exploring.
Methods: By setting the search terms correlated to PD-L1 and gastric cancer, a nearly
comprehensive search was carried out in four major databases, and the deadline for
searching was September 1, 2022. The retrieved documents were further screened by
strict inclusion and exclusion criteria after removing the duplication. Next, the quality of
the included studies was evaluated with the Newcastle-Ottawa Scale (NOS) scale. Finally,
the STATA15.1 software was used to process data and draw plots, and the odds ratios
(ORs) were adopted to assess the pooled effect size.
Results: A total of 85 works of literature were included in this study through screening
strictly, and detailed data were extracted after evaluating the quality of the literature.
The process of analysis was conducted in the whole population, Asia-Africa population,
European and American population, and Asian population with CPS≥1, amd all found
that the expression of PD-L1 in gastric cancer was correlated with age, tumor size, EBV
infection, Her-2 expression and microsatellite status. However, the subgroup of the region
also found some differences in Asian and Western regions, which was interesting
and worth studying further. The included research of this study did not have significant
publish bias.
Conclusion: After careful analysis, this study found that age (>60 years), tumor size
(>5cm), EBV infection (+), Her-2 expression (+), microsatellite status (MSI), and mismatch
repair status (dMMR) were risk factors for positive expression of PD-L1 in gastric
cancer.
