Title:Current Perspective and Mechanistic Insights on Bioactive Plant Secondary
Metabolites for the Prevention and Treatment of Cardiovascular Diseases
Volume: 23
Issue: 3
Author(s): Jyotika Grewal, Vijay Kumar, Yashika Gandhi, Hemant Rawat, Ravindra Singh, Arjun Singh, Ch. V. Narasimhaji, Rabinarayan Acharya and Sujeet K Mishra*
Affiliation:
- Central Ayurveda Research Institute Jhansi, Uttar Pradesh, 284003, India
Keywords:
Cardiovascular diseases, bioactive, phytocompounds, antioxidant, medicinal plants, therapeutic, antagonistic effects.
Abstract: Cardiovascular diseases (CVDs) are one of the most prevalent medical conditions of
modern era and are one of the primary causes of adult mortality in both developing and developed
countries. Conventional medications such as use of aspirin, beta-blockers, statins and angiotensin-
converting enzyme inhibitors involve use of drugs with many antagonistic effects.
Hence, alternative therapies which are safe, effective, and relatively cheap are increasingly being
investigated for the treatment and prevention of CVDs. The secondary metabolites of medicinal
plants contain several bioactive compounds which have emerged as alternatives to toxic modern
medicines. The detrimental effects of CVDs can be mitigated via the use of various bioactive
phytochemicals such as catechin, isoflavones, quercetin etc. present in medicinal plants. Current
review intends to accumulate previously published data over the years using online databases
concerning herbal plant based secondary metabolites that can help in inhibition and treatment of
CVDs. An in-depth review of various phytochemical constituents with therapeutic actions such
as antioxidant, anti-inflammatory, vasorelaxant, anti-hypertensive and cardioprotective properties
has been delineated. An attempt has been made to provide a probable mechanistic overview
for the pertinent phytoconstituent which will help in achieving a better prognosis and effective
treatment for CVDs.
