Title:Streptomyces Paradigm in Anticancer Therapy: A State-of-the Art Review
Volume: 20
Issue: 4
Author(s): Yashendra Sethi*, Vidhi Vora, Onyekachi Emmanuel Anyagwa, Nafisa Turabi, Maya Abdelwahab, Oroshay Kaiwan, Hitesh Chopra, Mohamed Shah Attia, Galal Yahya, Talha Bin Emran*Inderbir Padda
Affiliation:
- PearResearch, Dehradun 248001, India
- Department of Medicine, Government Doon Medical College, HNB Uttarakhand
Medical Education University, Dehradun, Uttarakhand, India
- Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh
Keywords:
Streptomyces, Mangrove streptomyces, anticancer drugs, anti-oxidative metabolites, Streptomyces monashensis, bleomycin.
Abstract: Cancer is one of the biggest threats to human health with a global incidence of 23.6 million,
mortality of 10 million, and an estimated 250 million lost in disability-adjusted life years
(DALYs) each year. Moreover, the incidence, mortality, and DALYs have increased over the past
decade by 26.3%, 20.9%, and 16.0%, respectively. Despite significant evolutions in medical therapy
and advances in the DNA microarray, proteomics technology, and targeted therapies, anticancer drug
resistance continues to be a growing concern and invites regular discovery of potent agents. One such
agent is the microbe-producing bioactive compounds like Streptomyces, which are proving increasingly
resourceful in anticancer therapy of the future. Streptomyces, especially the species living in
extreme conditions, produce bioactive compounds with cytolytic and anti-oxidative activity which
can be utilized for producing anticancer and chemo-preventive agents. The efficacy of the derived
compounds has been proven on cell lines and some of these have already established clinical results.
These compounds can potentially be utilized in the treatment of a variety of cancers including but not
limited to colon, lung, breast, GI tract, cervix, and skin cancer. The Streptomyces, thus possess the
armory to fuel the anticancer agents of the future and help address the problem of rising resistance to
currently available anti-cancer drugs. We conducted a state-of-art review using electronic databases
of PubMed, Scopus, and Google scholar with an objective to appraise the currently available literature
on Streptomyces as a source of anti-cancer agents and to compile the clinically significant literature
to update the clinicians.
