Research Article

姜黄素对氯吡硫磷慢性暴露所致心脏毒性的保护作用

卷 24, 期 5, 2024

发表于: 18 October, 2023

页: [676 - 682] 页: 7

弟呕挨: 10.2174/0115665240251646230919100920

价格: $65

摘要

目标:本研究旨在探讨氯吡硫磷(CPF)对大鼠心脏组织的影响和姜黄素(Cur)对心脏组织酶、氧化指标和组织病理学变化的影响。 背景:CPF是最常用的有机磷农药(OP),已被报道可引起心脏毒性作用。 目的:迄今为止,对枸杞抗CPF毒性的心脏保护作用尚未进行全面的研究。 方法:40只雄性Wistar大鼠随机分为5组(n=8)。C组(对照组,给予橄榄油)、CPF组(10 mg/kg/d)、CPF + Cur 25、CPF + Cur 50和CPF + Cur 100组(分别给予10 mg/kg/d CPF和25、50、100 mg/kg Cur)。所有治疗均采用灌胃治疗,疗程90 d。测量心脏组织中的心肌酶(LDH和CPK)和氧化应激(OS)生物标志物(丙二醛,超氧化物歧化酶)。心脏组织病理变化也进行了评估。 结果:慢性暴露于CPF显著增加心脏酶水平和OS生物标志物。组织学改变包括心肌纤维紊乱,心肌纤维紊乱变性,肌原纤维分离,心肌纤维胞浆空泡化。给药100 mg/kg的Cur可使cpf暴露动物血清LDH浓度和OS生物标志物恢复到正常水平(p < 0.05),并显著改善心脏损伤。 结论:本研究结果表明,姜黄素可通过调节OS降低长期暴露于CPF对大鼠心脏组织的不良影响。

关键词: 姜黄素,毒死蜱,氧化应激,心脏组织,大鼠,慢性暴露。

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