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Cardiovascular & Hematological Disorders-Drug Targets

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ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

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Research Article

Antidiabetic Effect of Star Anise (Illicium verum) in Streptozotocin-induced Diabetic Rats

Author(s): Smail Amtaghri, Adil Qabouche, Miloudia Slaoui and Mohamed Eddouks*

Volume 23, Issue 2, 2023

Published on: 05 October, 2023

Page: [92 - 98] Pages: 7

DOI: 10.2174/1871529X23666230823112113

Price: $65

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Abstract

Aim: The current study aimed to evaluate the antidiabetic potential of Illicium verum fruits.

Background: Illicium verum fruits are frequently used by the Moroccan population in the treatment of diabetes.

Methods: The antihyperglycemic effect of the aqueous extract of Illicium verum fruits (AEIVF) in rats was assessed. The effects of AEIVF (20 mg/kg) on glycemia and lipid profile as well as its phytochemical and antioxidant properties were evaluated.

Results: In normal and diabetic rats, AEIVF reduced blood glucose levels 6 hours after administration. Furthermore, after 7 days of treatment, glycemia was lowered in diabetic rats, and this extract exhibited an antioxidant activity.

Conclusion: The study shows that Illicium verum possesses a potent antidiabetic activity. In addition, the toxicity of AEIVF was evaluated and the LD50 value was found to be greater than the 2 g/kg dose.

Keywords: Illicium verum, antidiabetic, streptozotocin, antioxidant activity, phytochemical, oral glucose test tolerance, toxicity.

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