Title:A Comprehensive Review on Therapeutic Potential of a Natural
Anthraquinone Derivative Emodin in Brain-related Disorders
Volume: 24
Issue: 12
关键词:
EM、阿尔茨海默病、帕金森病、压力、癫痫、抑郁症、脑缺血、胶质母细胞瘤、脑内出血、创伤性脑损伤。
摘要: Brain-related disorders are one of the world’s most important and complex health
problems today. These brain-related disorders are responsible for a massive number of morbidities
and death all around the world. However, researchers have devoted a large amount of time to investigating
these diseases and found positive results; nevertheless, there are currently quite a few
medications available to treat them. Emodin (EM), a polyphenol compound, has many health benefits.
It is a biologically active monomer derived from rhubarb root that exhibits anti-inflammation,
anti-oxidation, anticancer, and neuroprotective properties. A series of preclinical trials have shown
EM to have protective benefits against many brain-related diseases. This review has evaluated the
potential of EM as a pharmacological agent for the treatment and management of various brain-related
disorders based on the findings of multiple pre-clinical studies and taking into account the
compound’s therapeutic properties.