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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Short Communication

One-pot Synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic Acid and DMF Derivatives using Imidazole Hydrochloride as a Promoter

Author(s): Yin Wang, Xiuyu Zhang, Suzhen Li, Mengyi Guo, Wanqian Ma and Jianyong Yuan*

Volume 21, Issue 7, 2024

Published on: 26 September, 2023

Page: [957 - 963] Pages: 7

DOI: 10.2174/1570179421666230815151540

Price: $65

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Abstract

As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed a wide range of functional group tolerance, and a series of quinazolinones were synthesized in low to moderate yields without metal catalysts, oxidants or other additives.

Keywords: Imidazole hydrochloride, 2, 3-disubstituted-4(3H)-quinazolinone, DMF derivatives, multicomponent reaction, Brönsted acid, transamidation.

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