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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

Application of Thermoresponsive Smart Polymers based in situ Gel as a Novel Carrier for Tumor Targeting

Author(s): Nidhi Sudhir Dhote, Rajat Dineshbhai Patel, Utkarsha Kuwar, Mukta Agrawal, Amit Alexander, Parag Jain and Ajazuddin*

Volume 24, Issue 4, 2024

Published on: 06 September, 2023

Page: [375 - 396] Pages: 22

DOI: 10.2174/1568009623666230803111718

Price: $65

Abstract

The temperature-triggered in situ gelling system has been revolutionized by introducing an intelligent polymeric system. Temperature-triggered polymer solutions are initially in a sol state and then undergo a phase transition to form a gel at body temperature due to various parameters like pH, temperature, and so on. These smart polymers offer a number of advantages, including ease of administration, long duration of release of the drug, low administration frequency with good patient compliance, and targeted drug delivery with fewer adverse effects. Polymers such as poly(N-isopropylacrylamide) (PNIPAAm), polyethylene glycol (PEG), poly (N, N′-diethyl acrylamide), and polyoxypropylene (PPO) have been briefly discussed. In addition to various novel Drug Delivery Systems (DDS), the smart temperature-triggered polymeric system has various applications in cancer therapy and many other disease conditions. This review focuses on the principals involved in situ gelling systems using various temperature-triggered polymers for chemotherapeutic purposes, using smart DDS, and their advanced application in cancer therapy, as well as available marketed formulations and recent advances in these thermoresponsive sol-gel transforming systems.

Keywords: In situ gelling, thermoresponsive, cancer, nanoparticles, tumor treatment, smart polymer.

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