Title:Cytotoxic and DNA-binding Capacity of Titanocene Functionalized
Mesoporous Nanoparticles in Breast Cancer Cell Lines MCF-7 and
MDA-MB-231
Volume: 29
Issue: 22
Author(s): Álvar Serrano-Pindado, Michael Aondona Iorhemba, Diana Díaz-García, Miguel Díaz-Sánchez, Irene Mena-Palomo, Santiago Gómez-Ruiz*Sanjiv Prashar*
Affiliation:
- COMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan
Carlos, Calle Tulipán s/n, Móstoles, E-28933, Madrid, Spain
- COMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan
Carlos, Calle Tulipán s/n, Móstoles, E-28933, Madrid, Spain
Keywords:
Titanocene, anticancer, mesoporous silica, DNA-binding, breast cancer, nanoparticles.
Abstract:
Aims: The fight against cancer is an active research topic that combines several disciplines to find
suitable agents to treat various tumours.
Background: Following cisplatin, organometallic compounds, including titanocene derivatives, have been tested
as antitumoral agents. However, key issues still need to be addressed in metallodrug chemotherapy relating
to solubility, stability, and dosage. Mesoporous silica nanoparticles, being low toxic biocompatible materials
with high loading capacity, are ideal candidates to overcome these problems.
Objective: This study aimed to prepare and structurally characterize titanocene functionalized mesoporous silica
nanoparticles and evaluate their cytotoxic activity against cancer cells.
Methods: The preparation of titanocene functionalized mesoporous silica nanoparticles was achieved by synthetic
protocols, involving either grafting or tethering. Characterization was carried out using standard techniques,
FT-IR, XRD, XRF, TEM, and BET. The titanocene functionalized materials were studied as antitumoral
agents in the breast cancer lines MCF-7 and MDA-MB-231.
Results: The functionalized MSN showed promising antitumoral activity against cells lines MCF-7 and MDAMB-
231 up to 9 times more than titanocene alone.
Conclusion: This study reported the potential of titanocene-functionalized mesoporous silica nanoparticles in
future chemotherapeutic actions.
