Title:A Critical Appraisal of Lipid Nanoparticles Deployed in Cancer
Pharmacotherapy
Volume: 17
Issue: 2
Author(s): Santanu Chakraborty, Manami Dhibar, Aliviya Das, Kalpana Swain and Satyanarayan Pattnaik*
Affiliation:
- Division of Advanced Drug Delivery, Talla Padmavathi College of Pharmacy, Warangal,
India
Keywords:
Lipid-based nanocarriers, nanomedicine, cancers, nanotoxicity, liposomes, solid lipid nanoparticles.
Abstract: Treatment modalities of various cancers and the delivery strategies of anticancer agents
have evolved significantly in the recent past. The severity and fatality of the disease and hurdles to the
effective delivery of therapeutic agents have drawn the attention of researchers across the world for
proposing novel and effective drug delivery strategies for anticancer therapeutics. Attempts have been
made to propose solutions to the diverse limitations like poor pharmacokinetics and higher systemic
toxicities of the traditional delivery of anticancer agents. Nanotechnology-based drug delivery systems
including lipid-based nanocarriers have demonstrated significant efficiency in this scenario. The review
critically assessed the different types of lipid nanocarrier systems for the effective and optimal
delivery of anticancer therapeutic agents. The diverse synthesis approaches are discussed for the laboratory
scale and commercial development of different categories of lipid nanocarriers. Further, their
application in anticancer drug delivery is illustrated in detail followed by a critical appraisal of their
safety and toxicity.
