Title:Recent Update on the Protective Potentials of Resveratrol against
Cisplatin-induced Ototoxicity: A Systematic Review
Volume: 31
Issue: 30
关键词:
肿瘤、顺铂、耳毒性、白藜芦醇、抗氧化、抗炎。
摘要:
Introduction: Although cancer treatment with cisplatin is effective, dose-dependent adverse
effects such as ototoxicity occurs often, which limits its clinical use. The use of resveratrol
may alleviate the cisplatin-induced ototoxic effects. This study is aimed to review the potential otoprotective
effects of resveratrol against cisplatin-induced ototoxicity.
Method: According to the PRISMA guideline, a systematic search was accomplished to identify
all relevant scientific papers on “the role of resveratrol against cisplatin-induced ototoxicity” in different
electronic databases up to May 2021. Fifty-five articles were screened based on a predefined
set of inclusion and exclusion criteria. Eight eligible studies were finally included in the
current systematic review. The in-vitro findings revealed that cisplatin administration significantly
decreased the HEI-OC1 cell viability compared to the untreated cells; however, resveratrol co-treatment
(in a dose-dependent manner) could protect HEI-OC1 cells against cisplatin-induced decrease
in cell viability.
Results: Furthermore, the in-vivo finding showed a decreased value of DPOAE, and increased values
of ABR threshold, ABR-I, ABR-IV, and ABR I-IV interval in cisplatin-treated animals; in contrast,
resveratrol co-administration demonstrated an opposite pattern on these parameters.
Conclusion: Thus, it can be mentioned that resveratrol co-treatment alleviates cisplatin-induced
ototoxicity. Mechanically, resveratrol exerts its otoprotective effects through various mechanisms
such as anti-oxidant, anti-apoptosis, and anti-inflammatory.
