Title:The Study of Risk Factors and The Predict Model of Cerebral Microbleeds
Volume: 20
Issue: 3
Author(s): Tao Lv*Changqing Li
Affiliation:
- Department of Neurology, The Second Affiliated Hospital Of Chongqing Medical University, ChongQing, China
Keywords:
Cerebral microbleeds, white matter hyperintensities, high CMBs burden, risk factors, prediction model, HPSAD3.
Abstract:
Background: To determine the association of cardiovascular risk factors with the presence
and anatomic location of CMBs and construct a factor-based evaluating model to predict a
high CMBs burden.
Methods: We assessed the relation of age, male, various cardiovascular risk factors, medication
use, stroke histories and white matter hyperintensities (WMH) to the presence and location of
CMBs with univariate analysis and multiple logistic regression. Finally, we added risk factors for a
high CMBs burden to a factor-based evaluating model score.
Results: 485 patients were included in our study. CMBs were more prevalent with advanced age,
male sex, more cardiovascular risk factors and WMH. Alcohol use, hemorrhagic stroke history and
the degree of deep white matter hyperintensity (DWMH) were independent predictors for a high
CMBs burden (≥10). We finally structured a prediction model-HPSAD3 that consisted of hypertension,
alcohol use, hemorrhagic stroke history and WMH to predict a high CMBs burden. The
model-HPSAD3 has a higher positive predict value (77.08%) and negative predict value (75.89%)
to predict a high CMBs burden when the cut-off score is 4.
Conclusions: Hypertension, alcohol use, hemorrhagic stroke history and WMH were added into
the model- HPSAD3, and there was a higher possibility of patients with CMBs ≥10 when the score
of HPSAD3 ≥4.
