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Recent Advances in Inflammation & Allergy Drug Discovery

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ISSN (Print): 2772-2708
ISSN (Online): 2772-2716

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Research Article

Association between Cardiac Atrioventricular Conduction and Antibodies to Chlamydia Pneumoniae in Fibromyalgia Patients

Author(s): Basant K. Puri*, Georgia Tuckey, Lucy Cowans, Gary S. Lee and Armin Schwarzbach

Volume 17, Issue 2, 2023

Published on: 10 August, 2023

Page: [127 - 132] Pages: 6

DOI: 10.2174/2772270817666230705140935

Price: $65

Abstract

Background: Fibromyalgia patients may complain of cardiovascular symptoms, including chest pain and palpitations. It has been proposed that infection by Chlamydia pneumoniae might be common in fibromyalgia. Chlamydia pneumoniae infection has also been hypothesized to be a causative factor in cardiac disease.

Objective: This study aims to test the hypothesis that there is an association between atrioventricular conduction and antibodies to Chlamydia pneumoniae in fibromyalgia.

Methods: Thirteen female fibromyalgia patients underwent serum Chlamydia pneumoniae IgG assays and 12-lead electrocardiography in a cross-sectional study. None of the patients was taking medication which might affect atrioventricular conduction, and none suffered from hypothyroidism, renal disease, hepatic disease, or carotid hypersensitivity.

Results: There was a significant positive correlation between the PR interval duration and the serum Chlamydia pneumoniae IgG level (r = 0.650; p = 0.016).

Conclusion: This study supports the hypothesis of an association between atrioventricular conduction and antibodies to Chlamydia pneumoniae in fibromyalgia patients. It suggests that the higher the level of such antibodies, the greater the electrocardiographic PR interval, and therefore the slower the atrioventricular conduction. Potential pathophysiological mechanisms include a chronic inflammatory response to Chlamydia pneumoniae and the action of the bacterial lipopolysaccharide. The latter may involve stimulators of interferon genes, activation of the cardiac NOD-like receptor protein 3 inflammasomes, and downregulation of fibroblast growth factor 5 in the heart.

Keywords: fibromyalgia, Chlamydia pneumoniae, antibody, immunoglobulin, electrocardiography, PR interval.

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[1]
Ghafouri B, Edman E, Löf M, et al. Fibromyalgia in women: Association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics. Pain Rep 2022; 7(6): e1042.
[http://dx.doi.org/10.1097/PR9.0000000000001042] [PMID: 36213597]
[2]
Alciati A, Atzeni F, Salaffi F, Sarzi-Puttini P. Onset and temporal sequencing patterns of comorbidity between lifetime major depression, panic disorder and fibromyalgia. Clin Exp Rheumatol 2022; 40(6): 1194-201.
[http://dx.doi.org/10.55563/clinexprheumatol/ryp027] [PMID: 35699055]
[3]
Alciati A, Nucera V, Masala IF, et al. One year in review 2021: fibromyalgia. Clin Exp Rheumatol 2021; 130(3): 3-12.
[http://dx.doi.org/10.55563/clinexprheumatol/gz4i3i]
[4]
Berwick RJ, Siew S, Andersson DA, Marshall A, Goebel A. A Systematic review into the influence of temperature on fibromyalgia pain: Meteorological studies and quantitative sensory testing. J Pain 2021; 22(5): 473-86.
[http://dx.doi.org/10.1016/j.jpain.2020.12.005] [PMID: 33421589]
[5]
Bruze M, Hopkins K, Dahlin J, et al. Increased rates of fragrance allergy in fibromyalgia individuals tested with the swedish baseline patch test series. J Eur Acad Dermatol Venereol 2022; 37: 104-13.
[http://dx.doi.org/10.1111/jdv.18562]
[6]
Ejiri Y, Uta D, Ota H, Mizumura K, Taguchi T. Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. Neurosci Res 2022; 181: 87-94.
[http://dx.doi.org/10.1016/j.neures.2022.03.005] [PMID: 35304863]
[7]
Emorinken A, Dic-Ijiewere MO, Erameh CO, Ugheoke AJ, Agbebaku FO, Agbadaola OR. Fibromyalgia in HIV-positive patients in nigeria: A cross-sectional prospective study. Int J Rheum Dis 2021; 24(10): 1273-81.
[http://dx.doi.org/10.1111/1756-185X.14195] [PMID: 34323376]
[8]
Hargreaves IP, Mantle D. Targeted treatment of age-related fibromyalgia with supplemental coenzyme Q10. Adv Exp Med Biol 2021; 1286: 77-85.
[http://dx.doi.org/10.1007/978-3-030-55035-6_5] [PMID: 33725346]
[9]
Klaver-Krol EG, Hermens HJ, Vermeulen RC, et al. Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load. Clin Neurophysiol 2021; 132(4): 967-74.
[http://dx.doi.org/10.1016/j.clinph.2020.11.043] [PMID: 33639451]
[10]
Mendoza-Muñoz M, Rodal M, García-Gordillo MÁ, et al. Spanish translation and cultural adaptation of the fibromyalgia knowledge questionnaire. Int J Environ Res Public Health 2021; 18(14): 7678.
[http://dx.doi.org/10.3390/ijerph18147678] [PMID: 34300129]
[11]
Mengshoel AM. A long, winding trajectory of suffering with no definite start and uncertain future prospects – narratives of individuals recently diagnosed with fibromyalgia. Int J Qual Stud Health Well-being 2022; 17(1): 2056956.
[http://dx.doi.org/10.1080/17482631.2022.2056956] [PMID: 35356859]
[12]
Sałat K, Furgała-Wojas A. Serotonergic neurotransmission system modulator, vortioxetine, and dopaminergic d2/d3 receptor agonist, ropinirole, attenuate fibromyalgia-like symptoms in mice. Molecules 2021; 26(8): 2398.
[http://dx.doi.org/10.3390/molecules26082398] [PMID: 33924258]
[13]
Tuncer M, Çoban K, Erbek SS, Erbek HS. Audiovestibular dysfunction in patients with fibromyalgia syndrome. J Int Adv Otol 2021; 17(4): 348-52.
[http://dx.doi.org/10.5152/JIAO.2021.8709] [PMID: 34309557]
[14]
Yoo SA, Kim CY, Kim HD, Kim SW. Effects of progressive muscle relaxation therapy with home exercise on pain, fatigue, and stress in subjects with fibromyalgia syndrome: A pilot randomized controlled trial. J Back Musculoskeletal Rehabil 2022; 35(2): 289-99.
[http://dx.doi.org/10.3233/BMR-191703] [PMID: 34151818]
[15]
Günlü S, Aktan A. Evaluation of the cardiac conduction system in fibromyalgia patients with complaints of palpitations. Cureus 2022; 14(9): e28784.
[http://dx.doi.org/10.7759/cureus.28784] [PMID: 36225502]
[16]
Contreras-Merino AM, Davydov DM, Galvez-Sánchez CM, Reyes del Paso GA. Blunted short-term autonomic cardiovascular reactivity to orthostatic and clinostatic challenges in fibromyalgia as an indicator of the severity of chronic pain. Int J Psychophysiol 2022; 175: 61-70.
[http://dx.doi.org/10.1016/j.ijpsycho.2022.03.001] [PMID: 35283267]
[17]
Aksu E, Berk E, Sökmen A, Sökmen G. Çelı̇k E. Subclinical cardiac structural and electrical abnormalities in fibromyalgia syndrome. Turk J Med Sci 2020; 50(4): 885-93.
[http://dx.doi.org/10.3906/sag-1912-228] [PMID: 32283905]
[18]
Rus A, Molina F, Martínez-Ramírez MJ, Aguilar-Ferrándiz ME, Carmona R, del Moral ML. Effects of olive oil consumption on cardiovascular risk factors in patients with fibromyalgia. Nutrients 2020; 12(4): 918.
[http://dx.doi.org/10.3390/nu12040918] [PMID: 32230754]
[19]
Gunturk EE, Ekiz T, Akkaya H. Evaluation of carotid-femoral pulse wave velocity, aortic stiffness index, and aortic distensibility in patients with fibromyalgia. Clin Rheumatol 2019; 38(6): 1731-5.
[http://dx.doi.org/10.1007/s10067-019-04429-0] [PMID: 30635854]
[20]
Triantafyllias K, Stortz M, de Blasi M, Leistner C, Weinmann-Menke J, Schwarting A. Increased aortic stiffness in patients with fibromyalgia: Results of a prospective study on carotidfemoral pulse wave velocity. Clin Exp Rheumatol 2019; 37(116 1): 114-5.
[21]
Acosta-Manzano P, Segura-Jiménez V, Estévez-López F, et al. Do women with fibromyalgia present higher cardiovascular disease risk profile than healthy women? the al-ándalus project. Clin Exp Rheumatol 2017; 35(105): 61-7.
[22]
Goldenberg DL. Do infections trigger fibromyalgia? Arthritis Rheum 1993; 36(11): 1489-92.
[http://dx.doi.org/10.1002/art.1780361102] [PMID: 8240426]
[23]
Machtey I. Chlamydia pneumoniae antibodies in myalgia of unknown cause (including fibromyalgia). Rheumatology 1997; 36(10): 1134a.
[http://dx.doi.org/10.1093/rheumatology/36.10.1134a] [PMID: 9374940]
[24]
Kuo CC, Grayston JT, Campbell LA, Goo YA, Wissler RW, Benditt EP. Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). Proc Natl Acad Sci 1995; 92(15): 6911-4.
[http://dx.doi.org/10.1073/pnas.92.15.6911] [PMID: 7624342]
[25]
Andrew P, Montenero AS. Is there a link between atrial fibrillation and certain bacterial infections? J Cardiovasc Med 2007; 8(12): 990-6.
[http://dx.doi.org/10.2459/JCM.0b013e32801411e5] [PMID: 18163009]
[26]
Grayston JT, Belland RJ, Byrne GI, et al. Infection with Chlamydia pneumoniae as a cause of coronary heart disease: The hypothesis is still untested#. Pathog Dis 2015; 73(1): 1-9.
[http://dx.doi.org/10.1093/femspd/ftu015] [PMID: 25854002]
[27]
Kostić T, Momčilović S, Perišić ZD, et al. Manifestations of lyme carditis. Int J Cardiol 2017; 232: 24-32.
[http://dx.doi.org/10.1016/j.ijcard.2016.12.169] [PMID: 28082088]
[28]
Clark BA, Prystowsky EN. Electrocardiography of atrioventricular block. Card Electrophysiol Clin 2021; 13(4): 599-605.
[http://dx.doi.org/10.1016/j.ccep.2021.07.001] [PMID: 34689889]
[29]
Bexton R S, Camm A J. First degree atrioventricular block Eur Heart J 1984; 5: 10: 7-9.
[http://dx.doi.org/10.1093/eurheartj/5.suppl_A.107]
[30]
Singh BN. Pharmacological basis for the therapeutic applications of slow-channel blocking drugs. Angiology 1982; 33(8): 492-515.
[http://dx.doi.org/10.1177/000331978203300802] [PMID: 7051905]
[31]
Bigger JT Jr. Cardiac electrophysiologic effects of moricizine hydrochloride. Am J Cardiol 1990; 65(8): 15-20.
[http://dx.doi.org/10.1016/0002-9149(90)91412-Y] [PMID: 2407089]
[32]
Wolfe F, Clauw DJ, Fitzcharles MA, et al. The american college of rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 2010; 62(5): 600-10.
[http://dx.doi.org/10.1002/acr.20140] [PMID: 20461783]
[33]
R core team R: A language and environment for statistical computing. In: Vienna, Austria: R Foundation for Statistical Computing 2022.
[34]
JASP team. jasp (version 0.16.3); university of amsterdam. 2022.
[35]
Hill AB. The environment and disease: Association or causation? J R Soc Med 2015; 108(1): 32-7.
[http://dx.doi.org/10.1177/0141076814562718] [PMID: 25572993]
[36]
Ma Y, Sun J, Che G, Cheng H. Systematic infection of chlamydia pneumoniae Clin Lab 2022; 68(08/2022)
[http://dx.doi.org/10.7754/Clin.Lab.2021.210908] [PMID: 35975489]
[37]
Gaydos CA, Summersgill JT, Sahney NN, Ramirez JA, Quinn TC. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect Immun 1996; 64(5): 1614-20.
[http://dx.doi.org/10.1128/iai.64.5.1614-1620.1996] [PMID: 8613369]
[38]
Makaryus JN, Catanzaro JN, Goldberg S, Makaryus AN. Rapid progression of atrioventricular nodal blockade in a patient with systemic lupus erythematosus. Am J Emerg Med 2008; 26(8): 967.e5-7.
[http://dx.doi.org/10.1016/j.ajem.2008.02.010] [PMID: 18926371]
[39]
Lopes-Virella MF. Interactions between bacterial lipopolysaccharides and serum lipoproteins and their possible role in coronary heart disease. Eur Heart J 1993; 14: 118-24.
[40]
Li N, Zhou H, Wu H, et al. STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol 2019; 24: 101215.
[http://dx.doi.org/10.1016/j.redox.2019.101215] [PMID: 31121492]
[41]
Song P, Shen DF, Meng YY, et al. Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway. Free Radic Biol Med 2020; 152: 186-96.
[http://dx.doi.org/10.1016/j.freeradbiomed.2020.02.011] [PMID: 32081748]
[42]
Cui S, Li Y, Zhang X, et al. FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII/NFκB signaling. Biochem Biophys Res Commun 2022; 636(Pt 2): 104-12.
[http://dx.doi.org/10.1016/j.bbrc.2022.10.080] [PMID: 36368152]

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