Natural Medicinal Compounds Used in Neurodegenerative Diseases

Sagarika      Majhi; Lubhan      Singh
doi:10.2174/2666862901666230627124045
Abstract

The medicinal plants discussed at this moment and their active isolated components seem promising for the treatment of neurodegenerative diseases viz. Disease (HD) in Huntington, Alzheimer's disease (AD), and Parkinson's disease (PD). These compounds can lay the groundwork for a new pharmacological approach to treatment, as patients tolerate herbal compounds more easily because they are relatively more protective than synthetic drugs. Meanwhile, there are anti-inflammatory, antioxidant, altered tau phosphorylation, anti-amyloidogenic, decreased aggregation of neurofibrillary tangles, and anticholinesterase processes in natural compound structures, including flavonoids, polyphenols, triterpenes, tannins, alkaloids and so on. We have summarized the pathogenesis and mechanism of different natural/bioactive components for treating HD, AD, and PD. An herbal source with well-established antioxidant and neuroprotective activity showed favourable impacts in both in vivo and in vitro studies against the symptoms of neurodegenerative diseases. The future outlook of herbal medicine can allow us to research their synergistic interactions, the action of multiple targets, and the elucidation of complex mechanisms of neuroprotective properties. However, in future scientific research on bioactive compounds, the efficacy of their active ingredients should be investigated to discover their neuroprotective therapeutic potential. Also, the mechanisms of action of herbal extracts and active ingredients remain to be clarified appropriately.
Keywords: Alzheimer's disease, huntington’s disease, parkinson’s disease, neurodegenerative disorders, neuroprotective agents, antioxidants.
Graphical Abstract

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DOI https://dx.doi.org/10.2174/2666862901666230627124045	Print ISSN 2666-8629
Publisher Name Bentham Science Publisher	Online ISSN 2666-8637
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