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Review Article

DNA和蛋白质甲基转移酶和去甲基化酶在人类疾病中的意义:从分子机制到新的治疗方法

卷 31, 期 23, 2024

发表于: 07 August, 2023

页: [3550 - 3587] 页: 38

弟呕挨: 10.2174/0929867330666230607124803

价格: $65

Open Access Journals Promotions 2
摘要

表观遗传机制是调控基因表达的关键。这些机制包括DNA甲基化和组蛋白修饰，如甲基化、乙酰化和磷酸化。DNA甲基化与基因表达抑制有关;然而，组蛋白甲基化可以刺激或抑制基因表达，这取决于组蛋白上赖氨酸或精氨酸残基的甲基化模式。这些修饰是介导环境对基因表达调控的关键因素。因此，它们的异常活动与各种疾病的发生有关。目前的研究旨在回顾DNA和组蛋白甲基转移酶和去甲基化酶在发展各种疾病中的意义，如心血管疾病、肌病、糖尿病、肥胖、骨质疏松症、癌症、衰老和中枢神经系统疾病。更好地了解表观遗传学在疾病发展中的作用可以为开发新的治疗方法铺平道路。

关键词: 表观遗传学，DNA甲基化，组蛋白甲基化，甲基转移酶，去甲基化酶，人类疾病。

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