Title:Drug Delivery Systems based on Microneedles for Dermatological
Diseases and Aesthetic Enhancement
Volume: 31
Issue: 23
关键词:
药物输送,微针,病变皮肤,美容增强,生物屏障,皮肤病。
摘要: Microneedle (MN) devices comprise of micron-sized structures that circumvent
biological barriers in a minimally invasive manner. MN research continues to grow
and evolve; the technology was recently identified as one of the top ten overall emerging
technologies of 2020. There is a growing interest in using such devices in cosmetology
and dermatological conditions where the MNs mechanically disrupt the outer skin barrier
layer, creating transient pathways that allow the passage of materials to underlying skin
layers. This review aims to appraise the application of microneedle technologies in skin
science, provide information on potential clinical benefits, as well as indicate possible
dermatological conditions that can benefit from this technology, including autoimmunemediated
inflammatory skin diseases, skin aging, hyperpigmentation, and skin tumors. A
literature review was carried out to select studies that evaluated the use of microneedles
to enhance drug delivery for dermatologic purposes. MN patches create temporary pathways
that allow the passage of therapeutic material to deeper layers of the skin. Given
their demonstrable promise in therapeutic applications it will be essential for healthcare
professionals to engage with these new delivery systems as they transition to the clinic.