Title:Potential Therapeutic Targets for the Management of Diabetes
Mellitus Type 2
Volume: 31
Issue: 21
关键词:
糖尿病，高血糖，分子靶点，葡萄糖稳态，代谢紊乱，胰岛素抵抗。
摘要: Diabetes is one of the lifelong chronic metabolic diseases which is prevalent
globally. There is a continuous rise in the number of people suffering from this disease with
time. It is characterized by hyperglycemia, which leads to severe damage to the body’s
system, such as blood vessels and nerves. Diabetes occurs due to the dysfunction of
pancreatic β -cell which leads to the reduction in the production of insulin or body cells
unable to use insulin produce efficiently. As per the data shared International diabetes
federation (IDF), there are around 415 million affected by this disease worldwide. There are
a number of hit targets available that can be focused on treating diabetes. There are many
drugs available and still under development for the treatment of type 2 diabetes. Inhibition
of gluconeogenesis, lipolysis, fatty acid oxidation, and glucokinase activator is emerging
targets for type 2 diabetes treatment. Diabetes management can be supplemented with drug
intervention for obesity. The antidiabetic drug sale is the second-largest in the world, trailing
only that of cancer. The future of managing diabetes will be guided by research on various
novel targets and the development of various therapeutic leads, such as GLP-1 agonists,
DPP-IV inhibitors, and SGLT2 inhibitors that have recently completed their different phases
of clinical trials. Among these therapeutic targets associated with type 2 diabetes, this
review focused on some common therapeutic targets for developing novel drug candidates
of the newer generation with better safety and efficacy.
