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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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General Review Article

Recent Advancement in Multicomponent Synthesis of Fused Coumarin Derivatives

Author(s): Vinita Yadav, Ajay Thakur, Ruchi Bharti*, Monika Verma and Renu Sharma

Volume 21, Issue 3, 2024

Published on: 07 July, 2023

Page: [303 - 330] Pages: 28

DOI: 10.2174/1570179420666230427110019

Price: $65

Abstract

The synthesis of coumarin derivatives has been an essential topic since its discovery in 1820. In bioactive compounds, the coumarin moiety serves as a backbone, as many such bioactive compounds with the coumarin moiety play a significant role in their bioactivities. Given this moiety's relevance, several researchers are developing fused-coumarin derivatives to create new drugs. Mostly the approach done for this purpose was a multicomponent reaction based. Over the years, the multicomponent reaction has gained enormous popularity, and this approach has evolved as a replacement for conventional synthetic methods. Because of all these perspectives, we have reported the various fused-coumarin derivatives synthesized using multicomponent reactions in recent years.

Keywords: Fused-coumarins, multicomponent reaction, natural coumarins, green approach, synthesis, benzopyrone.

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