Title:Current State of Platelet-rich Plasma in the Treatment of Rheumatic
Disease: A Retrospective Review of the Literature
Volume: 19
Issue: 4
Author(s): Adam Jacobs, Omar Elghawy, Diego Lugo Baruqui and Ahmed Aly Elghawy*
Affiliation:
- Department of Rheumatologic and Immunologic Disease, Cleveland Clinic, Cleveland, OH, United States
Keywords:
Platelet-rich plasma, rheumatic disease, rheumatoid arthritis, vasculitis, Sjogren’s syndrome, crystallinearthropathy, osteoarthritis.
Abstract:
Introduction: Rheumatic diseases are a spectrum of autoimmune or inflammatory diseases
that cause damage to the musculoskeletal system as well as vital organs, such as the heart,
lungs, kidneys, and central nervous system.
Methods: The study of rheumatic disease has made great progress in the understanding and management
of these conditions in the last few decades using disease-modifying antirheumatic drugs
and synthesized biological immunomodulating therapies. However, one potential treatment that has
not been well investigated in rheumatic disease is platelet-rich plasma (PRP). PRP is proposed to
facilitate the healing of injured tendons and ligaments through a variety of mechanisms, including
mitogenesis, angiogenesis and macrophage activation via cytokine release, although its exact mechanism
is unclear.
Result: There has been a great deal of work in determining the exact preparation method and composition
of PRP for regenerative purposes in orthopedic surgery, sports medicine, dentistry, cardiac
surgery, pediatric surgery, gynecology, urology, plastic surgery, ophthalmology, and dermatology.
Despite this, there is a paucity of research on the impact of PRP on rheumatic disease.
Conclusion: This study aims to summarize and evaluate the current research concerning the use of
PRP in rheumatic disease.
