Title:The Efficacy of Current Medications and Biomarkers in Hepatic Ischemia-
Reperfusion Damage
Volume: 2
Author(s): Jeetendra Kumar Gupta, Kuldeep Singh*, Krishanveer Singh and Shivendra Kumar
Affiliation:
- Department of Pharmacology, Institute of Pharmaceutical Research, GLA University Mathura, Uttar Pradesh, India
Keywords:
Preconditioning, inflammation, metalloproteinases, hepatic, ischemia, reperfusion injury.
Abstract: Hepatic ischemia-reperfusion injury is a complicated systemic process that affects several
tissues and organs in addition to being a pathologic process that affects the liver. Several studies
have shown that hepatic reperfusion severely impairs liver function. That also produces irreversible
damage that causes dysfunction of many organs. The regulation of hepatic ischemia-reperfusion
injury (IRI) is influenced by various factors, such as mitochondrial damage, anaerobic metabolism,
intracellular Ca2+ overload, oxidative stress and ROS production, and chemokines as well as cytokines
generation. Most of the cytokines are generated by helper T cells and neutrophils. A target of
Matrix Metalloproteinases (MMPs) in chronic and acute liver injury caused by ischemia can be a
significant facilitator of early leukocyte recruitment. Neutrophil gelatinase-associated lipocalin
(NGAL) and MMPs could be employed as indicators of the severity of ischemia-reperfusion (I-R)
injuries. This review examines the relationship between the components of hepatic IRI, MMPs, and
the available pharmaceutical treatments for this condition.
