Title:Lipidomics and Metabolomics in Infant Atopic Dermatitis: What’s the
Correlation with Early Nutrition?
Volume: 20
Issue: 4
Author(s): Angelica Dessì*, Camilla Di Maria, Roberta Pintus, Vassilios Fanos and Alice Bosco
Affiliation:
- Department of Surgical Sciences, University of Cagliari and Neonatal Intensive Care Unit, AOU Cagliari, Cagliari,
Italy
Keywords:
Atopic dermatitis, metabolomics, lipidomics, nutrition, infant, microbiota.
Abstract:
To date, the complex picture of atopic dermatitis (AD) has not yet been fully clarified,
despite the important prevalence of this disease in the pediatric population (20%) and the possibility
of persistence into adulthood, with important implications for the quality of life of those affected, as
well as significant social and financial costs. The most recent scientific evidence suggests a new interpretation
of AD, highlighting the important role of the environment, particularly that of nutrition
in the early stages of development. In fact, the new indications seem to point out the harmful effect
of elimination diets, except in rare cases, the uselessness of chrono-insertions during complementary
feeding and some benefits, albeit weak, of breastfeeding in those at greater risk.
In this context, metabolomics and lipidomics can be necessary for a more in-depth knowledge of the
complex metabolic network underlying this pathology. In fact, an alteration of the metabolic contents
in children with AD has been highlighted, especially in correlation to the intestinal microbiota.
While preliminary lipidomic studies showed the usefulness of a more in-depth knowledge of the alterations
of the skin barrier to improve the development of baby skin care products. Therefore, investigating
the response of different allergic phenotypes could be useful for better patient management
and understanding, thus providing an early intervention on dysbiosis necessary to regulate the
immune response from the earliest stages of development.
