Title:In vivo Analgesic Activity of New N-arylphthalimides Derivatives in Mice
Volume: 17
Issue: 2
Author(s): Asghar Davood*, Atefeh Saadabadi, Porya Torkaman, Ehsan Salehi and Hamed Shafaroodi
Affiliation:
- Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tehran Islamic Azad Medical Sciences University, Tehran, Iran
Keywords:
COX inhibitor, phthalimides, pain, formalin test, mice, sodium channel blocker.
Abstract:
Background: A series of phthalimides related to thalidomide have been studied for
analgesic activity in the formalin test. The formalin test was performed in mice in a nociceptive
pattern to evaluate analgesic activity.
Methods: In this study, nine derivatives of phthalimides were evaluated in terms of exerting analgesic
effects in mice. They exerted significant analgesic effects compared to indomethacin and
negative control. These compounds were synthesized and characterized by TLC, followed by IR
and H1NMR in the previous studies. Two distinct periods of high licking activity were used to
analyze both acute and chronic pain. All compounds were compared with indomethacin and carbamazepine
as positive control and vehicle as a negative control.
Results: All of the tested compounds exhibited significant analgesic activity in both the first and
second phases of the test compared to the control group (DMSO), although they did not show
more activity than the reference drug (indomethacin) but were comparable to indomethacin.
Conclusion: This information may be useful in the development of a more potent phthalimide as
an analgesic agent that acts as a sodium channel blocker and COX inhibitor.
