Title:Percutaneous Coronary Intervention Associated with a Higher Risk
of Hypoxemia and COVID-19 Severity
Volume: 31
Issue: 10
关键词:
2019冠状病毒病，新冠肺炎，经皮冠状动脉介入治疗，血管成形术，低氧血症，新发传染病。
摘要:
Objective: The primary goal of the present study was to measure the implications
of hypoxemia in COVID-19 patients with a history of coronary artery disease
(CAD).
Methods: A systematic search of the literature published from November 1, 2019 to May
1, 2021, was conducted on PubMed/MEDLINE, Embase, and Web of Science databases.
Afterwards, an observational study was designed based on the electronic health records
of COVID-19 patients hospitalized in a tertiary referral hospital during the same period.
A total of 179 COVID-19 cases were divided into two groups: cases with a history of
CAD and percutaneous coronary intervention (CAD/PCI+, n = 89) and controls (n = 90).
Clinical data were extracted from the electronic database of the hospital and statistically
analyzed.
Results: After the application of inclusion/exclusion criteria, only three studies were
deemed eligible, one of which was concerned with the impact of CAD on the all-cause
mortality of COVID-19. Results from our observational study indicated that the cases
were older (median age: 74 vs. 45) and more likely to develop hypoxemia (25.8% vs.
8.8%) than the controls. CAD/PCI+ was correlated with a more severe COVID-19 (11%
vs. 1%). Age was a moderately significant independent predictor of increased COVID-19
severity, while hypoxemia was not.
Conclusion: Considering the negative impact of hypoxemia on the prognosis of
COVID-19 and its higher prevalence among COVID-19 patients with underlying CAD,
further research is warranted to unravel the negative effects of COVID-19 on the mechanisms
of gas exchange and delivery in patients with pre-existing CAD.
