Title:Investigating Biomarkers for COVID-19 Morbidity and Mortality
Volume: 23
Issue: 13
Author(s): Flavio Maria Ceci, Giampiero Ferraguti, Marco Lucarelli, Antonio Angeloni, Enea Bonci, Carla Petrella, Silvia Francati, Christian Barbato, Maria Grazia Di Certo, Francesca Gabanella, Francesca Gavaruzzi, Claudio Maria Mastroianni, Antonio Minni, Antonio Greco, Massimo Ralli, Mauro Ceccanti, Luigi Tarani and Marco Fiore*
Affiliation:
- Institute of Biochemistry and Cell Biology (IBBC-CNR), Sapienza University of Rome, Rome, Italy
Keywords:
SARS-CoV-2, COVID-19, Albumin, Myoglobin, Early predictor, Biomarker.
Abstract:
Background and Objectives: This retrospective study aims to disclose further early parameters
of COVID-19 morbidity and mortality.
Methods: Three hundred and eighty-two COVID-19 patients, recruited between March and April
2020, were divided into three groups according to their outcome: (1) hospital ward group (patients
who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who attended
the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal outcome).
We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin amylase,
lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC,
PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the
hospitalization period.
Results: ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin,
lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of
fatal outcomes.
Conclusion: The present study confirms and extends the validity of routine laboratory biomarkers
(i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of
COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes
in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal outcomes.
