Title:Bloodborne Pancreatic Amylin, a Therapeutic Target for Alzheimer's
Disease
Volume: 19
Issue: 14
关键词:
脑积聚淀粉样蛋白β（Aβ），阿尔茨海默病（AD），血源性胰淀粉样蛋白，神经原纤维 tau 缠结，神经变性，血源性。
摘要: Alzheimer Disease (AD) pathology has been linked to brain accumulation of β amyloid
(Aβ) and neurofibrillary tau tangles. An intriguing question is whether targeting factors independent of
Aβ and tau pathologies could delay or even stop neurodegeneration. Amylin, a pancreatic hormone cosecreted
with insulin, is believed to play a role in the central regulation of satiation and was shown to
form pancreatic amyloid in persons with type-2 diabetes mellitus. Accumulating evidence demonstrates
that amyloid-forming amylin secreted from the pancreas synergistically aggregates with vascular
and parenchymal Aβ in the brain in both sporadic and early-onset familial AD. Pancreatic expression
of amyloid-forming human amylin in AD-model rats accelerates AD-like pathology, whereas genetically
suppressed amylin secretion protects against AD effects. Thus, current data suggest a role of
pancreatic amyloid-forming amylin in modifying AD; further research is required to test whether lowering
circulating amylin levels early during AD pathogenesis may curb cognitive decline.
