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Research Article

自闭症谱系障碍成人中 5-HT 和 BDNF 的循环水平：对自闭症谱系障碍受试者及其一级亲属和对照样本的调查

卷 31, 期 6, 2024

发表于: 08 March, 2023

页: [776 - 790] 页: 15

弟呕挨: 10.2174/0929867330666230131115031

价格: $65

摘要

背景：几项研究调查了自闭症谱系障碍(ASD)儿童血清素(5- HT)和脑源性神经营养因子(BDNF)的循环水平。更多有限的文献集中在ASD成人或亚阈下自闭症谱系表现的人群，如ASD先证者的亲属。本研究旨在探讨成人自闭症谱系条件下5-HT和BDNF的水平。还评估了生化变量水平与ASD症状之间的相关性。 方法：招募ASD成人、他们的一级亲属(广泛自闭症表型，BAP组)和对照组，并使用心理测量量表进行评估。采集了所有参与者的血液样本。采用ELISA试剂盒检测5-HT和BDNF水平。 结果：与BAP组和对照组相比，ASD成人的血小板贫化血浆(PPP) 5-HT水平显著降低。各组间PPP BDNF水平和血小板内5-HT水平无显著差异。据报道，5-羟色胺水平与某些自闭症症状特异性相关。 结论：这项研究强调，与其他组相比，ASD成人中PPP 5-HT水平降低，而BDNF水平没有显著差异，这支持了成人ASD的生化相关因素可能不同于儿童的假设。

关键词: BDNF，血清素，自闭症，广泛的自闭症表型，生化相关，先证者。

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