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Review Article

LSINCT5:一种新的肿瘤lncRNA

卷 30, 期 39, 2023

发表于: 16 February, 2023

页: [4409 - 4420] 页: 12

弟呕挨: 10.2174/0929867330666230123144602

价格: $65

摘要

背景：长链非编码rna (Long chain non-coding rna, lncRNA)是一种长度约为200个核苷酸的转录物，可以通过表观遗传、转录和转录后调控参与生命活动。lncrna的关键成员之一，长应力诱导的非编码转录本5 (LSINCT5)，定位于Chr 5p，据报道在一系列癌症中异常表达。我们对恶性肿瘤中LSINCT5的异常表达及其调控机制进行了全面的综述。 方法：使用关键词“LSINCT5”和“Cancer”通过PubMed数据库对纳入的研究进行检索和汇总。 结果：LSINCT5作为一种致癌基因，在恶性肿瘤的发生和发展中大量表达。LSINCT5通过海绵microrna (miRNA)，与蛋白相互作用，参与细胞转导，并受转录因子调控，可刺激多种肿瘤细胞的恶性行为，包括增殖、迁移、侵袭和上皮间质转化(EMT)。此外，失调的LSINCT5通常与不良预后相关。 结论：LSINCT5有潜力成为肿瘤诊断和预后标志物，为临床应用提供新的途径。

关键词: LncRNA, LSINCT5，肿瘤，机制，生物标志物，诊断，治疗，预后。

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