Title:High Value Compounds and Bioactivity of Rice Bran, Rice Bran Protein:
A Review
Volume: 14
Issue: 1
Author(s): Pratap Kalita*, Abdul Baquee Ahmad, Saikat Sen, Bhargab Deka, Quri Kiran Hazarika, Manas Jyoti Kapil and Lalduhsanga Pachuau
Affiliation:
- Department of Pharmaceutics, Pratiksha Institute of Pharmaceutical Sciences, Guwahati, Assam, 781026, India
- Assam Science Technology University, Guwahati, Assam, 781013, India
Keywords:
Rice bran, rice bran protein, high-value compounds, bioactivity mechanisms, therapeutical, apoptotic.
Abstract: Rice bran and rice bran protein are important sources of minerals, energy, and vitamins.
Other bioactive compounds are abundantly available to exert therapeutical activity. Healthpromoting
activities of high-value compounds of rice bran were significant, as observed in recent
studies. A variety of bioactive components present in rice bran and rice bran extract are responsible
to exhibit therapeutical potential like chemopreventive, cardioprotective, hepatoprotective,
immunomodulatory, neuroprotective, and lipid-lowering activity. Several bioactivity representative
compounds like γ-oryzanol, ferulic acid, caffeic acid, tricin, protocatechuic acid, vanillic acid,
coumaric acid, phytic acid, isoferulic acid, gallic acid, γ-amino butyric acid, sinapic acid, saturated
and unsaturated fatty acids, vitamin E complexes, β-sitosterol, stigmasterol, campesterol,
cyanidin-3-glucoside, peonidin-3-glucoside, quercetin, rutin, kaemferol, β-carotene, lutein, vitamin
B and lycopene are known to display significant health benefits. The bioactive components
produced therapeutical effects by regulation of different mechanisms like increasing faecal excretion,
reducing oxidative stress, reducing the level of malondialdehyde (MDA), regulation of
NF-kb activation, reduction of proinflammatory cytokines production, suppression of SREBP-1,
reduction in the expression of anti-apoptotic protein Bcl-2, elevated the expression of proapoptotic
protein Bax, up-regulating P53 expression and suppressing COX-2. Several research
engines like PubMed, google scholar, science direct, etc. were used to collect the data on the mentioned
keywords. Recent scientific works were included in this article. In this review paper, we
profiled the high-value compounds and focused on their antioxidant, anti-hyperlipidemic, antidiabetic,
and anticancer activity with their possible mechanism of action.
